Thermo Fisher Scientific NF2 Polyclonal Antibody
Rabbit polyclonal antibody targeting NF2 (Merlin) protein. Validated for WB, IHC, IHC-P, and IP applications. Recommended for FFPE tissue with citrate buffer retrieval. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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- A300578Ax (2개 옵션)
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1–4 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and the C-terminus (residue 595) of human Neurofibromin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
NF2 encodes a protein, Merlin, that is similar to members of the ERM family of proteins which link cytoskeletal components with membrane proteins. Merlin interacts with cell-surface proteins, cytoskeletal regulators, and ion transport proteins.
This gene is highly expressed during embryonic development and in adults is found in Schwann cells, meningeal cells, lens, and nerve.
Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors, and ocular abnormalities.
Multiple isoforms are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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