Thermo Fisher Scientific TNFRSF21 Monoclonal Antibody (4D8)
인간 TNFRSF21 단백질을 인식하는 마우스 단클론 항체로, ELISA에 적합합니다. Affinity chromatography로 정제되었으며, 보존제가 없는 PBS(pH 7.4) 용액 형태입니다. DR6 수용체 연구 및 세포 사멸 신호 경로 분석에 활용됩니다.
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Applications
- ELISA (ELISA): 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D8 |
| Immunogen | TNFRSF21 (AAH17730.1, 47 a.a. ~ 214 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ASNLIGTYRH VDRATGQVLT CDKCPAGTYV SEHCTNTSLR VCSSCPVGTF TRHENGIEKC HDCSQPCPWP MIEKLPCAAL TDRECTCPPG MFQSNATCAP HTVCPVGWGV RKKGTETEDV RCKQCARGTF SDVPSSVMKC KAYTDCLSQN LVVIKPGTKE TDNVCGTL
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 (death receptor-6). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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