Thermo Fisher Scientific HEXB Polyclonal Antibody
Human HEXB 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P) 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. Sandhoff 병 연구 등 HEXB 관련 단백질 분석에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HEXB. Recombinant protein control fragment (Product #RP-100907) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642407 |
Product Specific Information
Immunogen sequence:
FGFYKWHHEP AEFQAKTQVQ QLLVSITLQS ECDAFPNISS DESYTLLVKE PVAVLKANRV W
Highest antigen sequence identity to orthologs:
- Mouse: 72%
- Rat: 69%
Target Information
Hexosaminidase B (HEXB), also known as β-hexosaminidase B, is a tetramer composed of two β-A and two β-B chains located in lysosomes.
Mutations in the HEXB gene cause Sandhoff disease (GM2-gangliosidosis type II), a rare autosomal recessive disorder leading to accumulation of GM2 ganglioside and progressive neurodegeneration.
Sandhoff disease is similar to Tay-Sachs disease (HEXA mutation), but generally more severe.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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