Thermo Fisher Scientific Phospho-EIF2S1 (Ser52) Polyclonal Antibody
Phospho-EIF2S1 (Ser52) 특이적 폴리클로날 항체로, 인산화된 eIF2α 검출에 적합. Western blot, IHC, ICC/IF에 사용 가능. 사람, 마우스, 랫트 반응성. PBS/50% glycerol 보존, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EIF2S1 (Accession P05198), corresponding to amino acid residues around phosphorylated Ser52. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899206 |
Product Specific Information
This antibody detects endogenous levels of eIF2 alpha only when phosphorylated at Ser52, a site historically referenced as Ser51.
Target Information
EIF2α (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor mediates the binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by stress-activated protein kinases. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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