Thermo Fisher Scientific GSK3 alpha/beta Polyclonal Antibody
GSK3 alpha/beta 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 등 다양한 종에 반응. Affinity chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. 연구용 전용 제품.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GSK3A (Accession P49840), corresponding to amino acid residues P254–W304 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818464 |
Product Specific Information
This antibody detects endogenous levels of total GSK3 alpha/beta.
Target Information
Glycogen synthase kinase-3 (GSK3) is a protein kinase originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. It is involved in various cellular functions including protein synthesis, cell proliferation, differentiation, microtubule dynamics, and apoptosis.
GSK3 phosphorylates substrates only if a phosphoserine or phosphotyrosine is present four residues C-terminal to the phosphorylation site. Two isoforms exist, GSK3 alpha and GSK3 beta, which are regulated by phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes inactivation, while activation requires phosphorylation of Tyr216 (Tyr279 in GSK3 alpha).
Activated GSK3 beta phosphorylates multiple cellular proteins such as p53, c-Myc, c-Jun, HSF-1, and cyclin D1, and contributes to phosphorylation of tau protein, implicated in Alzheimer’s disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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