Thermo Fisher Scientific ZBTB5 Polyclonal Antibody
ZBTB5 단백질을 인식하는 Thermo Fisher의 폴리클로날 항체로, WB, IHC, ICC, ELISA 등에 사용 가능. Rabbit IgG 기반으로 제작되었으며, Human, Mouse, Rat에 반응. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
- 카탈로그번호
- BS-13581R
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human ZBTB5 (amino acids 581–677) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ZBTB family of proteins comprises diverse zinc finger proteins that also contain a BTB (BR-C, ttk, and bab) domain. ZBTB5 was identified through sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. It binds DNA and directly represses transcription of the cell cycle arrest gene p21. ZBTB5 interacts with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, leading to deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. This activity promotes cell proliferation and cell cycle progression, suggesting that ZBTB5 may function as a potential proto-oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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