Thermo Fisher Scientific CRALBP Polyclonal Antibody
인체 CRALBP 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:5,000–1:10,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 시료는 PBS(40% 글리세롤, 0.02% sodium azide) 완충액에 보관. RPE 및 Muller glial cell 연구용에 적합.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RLBP1. Recombinant protein control fragment (Product # RP-106021) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790741 |
Product Specific Information
Immunogen sequence:
TTKDHGPVFG PCSQLPRHTL QKAKDELNER EETREEAVRE LQEMVQAQAA SGEELAVAVA ERVQEKDSGF FLRFIRARKF NVGRAYELLR GYVNFRL
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP).
Genetic mutations involving CRALBP’s lack of function have been linked to visual diseases such as Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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