
Thermo Fisher Scientific ZNF598 Polyclonal Antibody
ZNF598 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공.
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Thermo Fisher Scientific ZNF598 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 106–340 of Human ZNF598 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.29 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548883 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat, Raji
- Predicted reactivity: Zebrafish (85%), Xenopus laevis (84%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC).
RQC is a pathway that occurs when a ribosome stalls during translation.
ZNF598 mediates monoubiquitination of ribosomal proteins RPS10/eS10 and RPS3/uS3, enabling terminal stalling during translation of poly(A) sequences.
This mechanism prevents synthesis of aberrant poly-lysine tails and initiates the RQC pathway to degrade potentially detrimental nascent polypeptides.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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