Thermo Fisher Scientific Pan-CDH Monoclonal Antibody (OTI5G2), TrueMAB
인간 Cadherin 패밀리를 인식하는 마우스 단클론 항체로, IHC(P)에서 1:150 희석으로 사용 가능. 액상 형태의 비결합 항체이며, -20°C에서 보관. 세포 간 칼슘 의존적 접착 연구에 적합한 연구용 시약.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5G2 |
| Immunogen | Synthetic peptide corresponding to the conserved region of human cadherin family |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Pan Cadherin (including CDH1, CDH2, CDH3, CDH4) proteins belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins control morphogenetic movements during development and regulate cell surface adhesion through homotypic interactions with the same cadherin species.
N-cadherin function depends on its association with the actin cytoskeleton via interactions between its C-terminal region and cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.
This gene encodes a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. It functions during gastrulation and is required for the establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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