Thermo Fisher Scientific Pan-CDH Monoclonal Antibody (OTI5G2), TrueMAB

Applications

• Immunohistochemistry (Paraffin) [IHC (P)]: 1:150

Product Specifications

Target Information

Pan Cadherin (including CDH1, CDH2, CDH3, CDH4) proteins belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins control morphogenetic movements during development and regulate cell surface adhesion through homotypic interactions with the same cadherin species.
N-cadherin function depends on its association with the actin cytoskeleton via interactions between its C-terminal region and cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.
This gene encodes a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. It functions during gastrulation and is required for the establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.