Thermo Fisher Scientific NREP Polyclonal Antibody
Rabbit polyclonal antibody recognizing human C5orf13 (P311) protein. Suitable for IHC (paraffin) applications with dilution 1:50–1:100. Supplied as liquid, 1 mg/mL concentration. For research use only, not for diagnostic or resale purposes.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human C5orf13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555893 |
Target Information
P311, also known as C5orf13 (chromosome 5 open reading frame 13), D4S114, PTZ17 or PRO1873, is a 68 amino acid cytoplasmic protein involved in cellular differentiation, neural function, and axonal regeneration. Found in the granular layer of the cerebellum, P311 is expressed at lower levels in hippocampus, olfactory bulb, kidney, liver, and heart. When expressed ectopically, P311 augments glioma motility. It is enriched in mice within the superficial cortical layers and striatum at E20 and the germinal zones at E17. Known to interact with Filamin 1, P311 regulates retinoic-acid lipid-droplet biogenesis, induces myofibroblast ameboid migration, and promotes the differentiation of fibroblasts into myofibroblasts. Ser-59 phosphorylation decreases P311 stability; the gene encoding P311 maps to human chromosome 5q22.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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