Thermo Fisher Scientific MARK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human MARK1. Recombinant protein control fragment (Product #RP-89778). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MARK1,uniProtId:Q9P0L2-1,ncbiNodeId:9606,antigenRange:555-657,antigenLength:795,antigenImageFileName:PA5-110728_MARK1_Q9P0L2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110728_MARK1_Q9P0L2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856139

Product Specific Information

Immunogen sequence: MSTSGHPIKV TLPTIKDGSE AYRPGTTQRV PAASPSAHSI STATPDRTRF PRGSSSRSTF HGEQLRERRS VAYNGPPASP SHETGAFAHA RRGTSTGIIS KIT

Target Information

MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.