Thermo Fisher Scientific GRM5 Polyclonal Antibody
Rabbit polyclonal antibody against human GRM5. Validated for Western blot applications. High purity via antigen affinity chromatography. Supplied in PBS with 50% glycerol for stability. For research use only.
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- TA890123
- 판매단위
- pk
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human GRM5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.51 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein. Diseases associated with GRK1 dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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