Thermo Fisher Scientific GRM5 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein. Diseases associated with GRK1 dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.