Thermo Fisher Scientific Human MAPK10 (JNK3), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Protein Form: Full Length

Target Information

MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs).
It is involved in neuronal apoptosis and phosphorylates MAP2K4.
MAP kinases act as integration points for multiple biochemical signals and are involved in cellular processes such as proliferation, differentiation, transcription regulation, and development.
This kinase plays regulatory roles in neuronal apoptosis through phosphorylation and nuclear localization.
Beta-arrestin 2 interacts with and stimulates phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4).
Cyclin-dependent kinase 5 can phosphorylate and inhibit JNK3 activity, potentially preventing neuronal apoptosis.
Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.