Thermo Fisher Scientific DGUOK Polyclonal Antibody
Thermo Fisher Scientific의 DGUOK Polyclonal Antibody는 인간 DGUOK 단백질을 인식하는 rabbit IgG 폴리클로날 항체입니다. Western blot 및 IHC(P) 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DGUOK. Recombinant protein control fragment (Product #RP-95995). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640554 |
Product Specific Information
Immunogen sequence:
STFVKLLTKT YPEWHVATEP VATWQNIQAA GTQKACTAQS LGNLLDMMYR EPARWSYTFQ TFSFLSRLKV QLEPFPEKLL QARKPVQI
Antigen sequence identity:
Mouse – 75%, Rat – 77%
Target Information
Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. These analogs are used in treatment of lymphoproliferative disorders and require intracellular phosphorylation to triphosphates for activity. In mammalian cells, phosphorylation of purine deoxyribonucleosides is mediated mainly by cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK, also known as DGK). DGUOK is expressed ubiquitously, with highest levels in muscle, brain, liver, and lymphoid tissues. Defects in DGUOK cause mitochondrial DNA depletion syndrome (MDS), a heterogeneous group of disorders characterized by reduction in mitochondrial DNA copy number. MDS is inherited as an autosomal recessive trait and may affect single or multiple organs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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