Thermo Fisher Scientific CP110 Polyclonal Antibody
Rabbit polyclonal antibody against human CP110 protein. Validated for Western blot and immunoprecipitation. Essential for studying centrosome duplication and ciliogenesis. Supplied as unconjugated liquid, 0.2 mg/mL, stored at 4°C.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 962 and 1012 of human centrosomal protein 110kDa (CP110) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
CP110 is necessary for centrosome duplication at different stages of procentriole formation. It acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole, thereby preventing cilia formation (PubMed:17719545, 17681131, 23486064).
It is also involved in promoting ciliogenesis and may play a role in assembling the mother centriole subdistal appendages (SDA), affecting the fusion of recycling endosomes to basal bodies during cilia formation.
Required for correct spindle formation and participates in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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