Thermo Fisher Scientific ATP6AP1 Polyclonal Antibody
ATP6AP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 면역세포염색에 적합. 인간 반응성, 토끼 IgG 호스트. 합성 펩타이드 면역원 사용, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human ATP6AP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607723 |
Product Specific Information
- Peptide sequence: SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS
- Sequence homology:
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 86%
Rat: 100%
Target Information
Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP. The enzyme consists of a peripheral V1 domain (responsible for ATP hydrolysis) and an integral V0 domain (responsible for proton translocation).
ATP6AP1 (ATPase, H⁺ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1, or ATP6IP1, is a type I transmembrane V-ATPase accessory protein predominantly expressed in endocrine and neuronal cells. It plays a key role in targeting V-ATPase to specialized vacuolar systems and interacts with V0 domain subunits through its cytoplasmic tail. Disruption of this interaction in osteoclasts impairs bone resorption, indicating its importance in osteoclastic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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