Thermo Fisher Scientific NFKBIE Monoclonal Antibody (OTI6D8), TrueMAB
인간 NFKBIE 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적 저장이 가능합니다. NF-kappa-B 신호 억제 연구에 활용됩니다.
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Applications
- Western Blot (WB): 1:500–1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6D8 |
| Immunogen | Full length human recombinant NFKBIE protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NFKB1 or NFKB2 binds to REL, RELA, or RELB to form the NFKB complex. This complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which retain NF-kappa-B in the cytoplasm. Phosphorylation of I-kappa-B proteins by kinases (IKBKA or IKBKB) leads to their ubiquitination and degradation, enabling NF-kappa-B activation. Activated NF-kappa-B translocates to the nucleus and binds DNA at kappa-B motifs (5′-GGGRNNYYCC-3′ or 5′-HGGARNYYCC-3′). Some gene activations require interactions with transcription factors such as STAT6, AP1, and NFATC1.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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