Thermo Fisher Scientific ANKRD20A3 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent

Product Specifications

Target Information

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis.
ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein containing five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes.
Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male-to-female sex reversal, the phenotype of a female with a male X,Y genotype.
Hereditary hemorrhagic telangiectasia, characterized by harmful vascular defects, and familial dysautonomia are associated with chromosome 9.
Additionally, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.