Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Human PABPC4 단백질을 인식하는 Rabbit Polyclonal Antibody로 다양한 응용(WB, IHC, ICC, IP)에 사용 가능. 고순도 항원 친화 크로마토그래피로 정제되었으며, 연구용으로 안정적인 저장 조건 제공. T세포 활성화 및 mRNA 안정성 연구에 적합.
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Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,500 |
| Immunoprecipitation (IP) | 1–2 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human PABPC4 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2867069 |
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4, also known as inducible PABP (IPABP), was identified as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains four RNA-binding domains and a proline-rich C terminus, and is primarily localized in the cytoplasm. It may be necessary for regulating the stability of labile mRNA species in activated T cells.
Additionally, PABPC4 was identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. It may also play roles in protein translation regulation in platelets and megakaryocytes, or in binding/stabilization of polyadenylates in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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