Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4, also known as inducible PABP (IPABP), was identified as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.

PABPC4 contains four RNA-binding domains and a proline-rich C terminus, and is primarily localized in the cytoplasm. It may be necessary for regulating the stability of labile mRNA species in activated T cells.

Additionally, PABPC4 was identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. It may also play roles in protein translation regulation in platelets and megakaryocytes, or in binding/stabilization of polyadenylates in platelet dense granules.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.