Thermo Fisher Scientific PTPRB Monoclonal Antibody (2-A2)
PTPRB 단백질을 인식하는 2-A2 클론 마우스 단일클론 항체. 인간 및 생쥐 시료에 반응하며 ICC/IF에 적합. 고순도 Protein G 정제, 액상 형태로 제공. 안정적 저장용 PBS 버퍼에 글리세롤 및 BSA 포함.
- 카탈로그번호
- MA532904
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2-A2 |
| Immunogen | Recombinant protein within Human PTPRB aa 1,018–1,161 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802539 |
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains an extracellular domain, a single transmembrane segment, and one intracytoplasmic catalytic domain, classifying it as a receptor-type PTP.
Its extracellular region is composed of multiple fibronectin type III repeats that interact with neuronal receptors and cell adhesion molecules such as contactin and tenascin C.
Additionally, it interacts with sodium channels, potentially regulating them by altering tyrosine phosphorylation status. These interactions suggest roles in cell adhesion, neurite growth, and neuronal differentiation.
Alternate transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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