Thermo Fisher Scientific PIK3C2A Polyclonal Antibody
Rabbit polyclonal antibody targeting human PIK3C2A. Validated for Western blot at 1:500 dilution. Unconjugated, liquid form with 1 mg/mL concentration. Suitable for research use in signaling and kinase pathway studies.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PIK3C2A (amino acids 1601–1622) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2692205 |
Product Specific Information
Predicted to react with Mouse samples.
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, Class II enzymes are linked to diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases play roles in pathways involved in cell proliferation, oncogenic transformation, survival, migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain and a C-terminal C2 domain typical of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid-binding motifs, mediating protein translocation to membranes and protein-protein interactions.
The PI3-kinase activity of this protein is not sensitive to nanomolar levels of wortmannin. It can be activated by insulin and may participate in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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