Thermo Fisher Scientific PIK3C2A Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

Predicted to react with Mouse samples.

Target Information

The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, Class II enzymes are linked to diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases play roles in pathways involved in cell proliferation, oncogenic transformation, survival, migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain and a C-terminal C2 domain typical of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid-binding motifs, mediating protein translocation to membranes and protein-protein interactions.
The PI3-kinase activity of this protein is not sensitive to nanomolar levels of wortmannin. It can be activated by insulin and may participate in integrin-dependent signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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