Thermo Fisher Scientific SEMA4D Monoclonal Antibody (OTI6G1), TrueMAB
Human SEMA4D 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 IHC(P) 검증 완료. TrueMAB 포맷으로 높은 특이성과 재현성을 제공. 연구용으로 B 세포 신호 조절 및 신경계 발달 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G1 |
| Immunogen | Full length human recombinant protein of human SEMA4D produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, induces B cell aggregation and improves viability in vitro.
It modulates CD40–CD40L B cell signaling by enhancing aggregation and survival while downregulating CD23 expression.
CD72 acts as a lymphocyte receptor for CD100, regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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