Thermo Fisher Scientific Cathepsin L Recombinant Mouse Monoclonal Antibody (12H6)

Applications and Tested Dilution

Product Specifications

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies, myocardial ischemia, and the renal tubular response to proteinuria. This protein, a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.

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