Thermo Fisher Scientific Diazepam Binding Inhibitor Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Diazepam Binding Inhibitor (DBI). Validated for WB and IHC. Synthetic peptide immunogen (aa 1–50). Supplied as liquid, 0.5 mg/mL in PBS with sucrose and sodium azide. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human DBI (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609670 |
Product Specific Information
Peptide sequence:
MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF
Sequence homology:
Cow: 86%
Dog: 79%
Guinea Pig: 92%
Human: 100%
Mouse: 85%
Rabbit: 86%
Rat: 92%
Target Information
This gene encodes diazepam binding inhibitor (DBI), a protein regulated by hormones and involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines that modulate signal transduction at type A gamma-aminobutyric acid (GABA-A) receptors located in brain synapses.
The protein is conserved from yeast to mammals, with the most highly conserved domain comprising seven contiguous residues forming the hydrophobic binding site for medium- and long-chain acyl-CoA esters.
DBI also mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin, and participates in corticotropin-dependent adrenal steroidogenesis.
Three pseudogenes have been identified on chromosomes 6, 8, and 16. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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