Thermo Fisher Scientific CRTH2 Polyclonal Antibody
Thermo Fisher Scientific의 CRTH2 Polyclonal Antibody는 인간 CRTH2(GPR44)를 표적으로 하는 토끼 유래 IgG 항체로, IHC(P) 및 ELISA에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 알레르기 반응 및 Th2 세포 연구에 활용됩니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 15 µg/mL
- 참고: Heat-induced antigen retrieval in pH 6.0 citrate buffer 권장
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human GPR44 / CRTH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550291 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
- Human, Gorilla: 100%
- Pig: 85%
- Elephant: 80%
- For IHC(P): Use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were treated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells, acting as a receptor for prostaglandin D2 (PGD2).
It mediates chemotaxis of Th2 cells and eosinophils, playing a key role in allergic responses.
CRTH2-deficient mice exhibit enhanced eosinophil recruitment and elevated IL-5 and IL-3 levels, indicating its role in restricting eosinophilia.
CRTH2 is selectively expressed in Th2 lineage cells, with two known transcripts (3.5 kb and 3.4 kb) found in the brain and immune tissues.
Single nucleotide polymorphisms in the CRTH2 gene 3’ UTR have been associated with asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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