Thermo Fisher Scientific GnRHR Polyclonal Antibody
Rabbit polyclonal antibody targeting human GnRHR. Validated for IHC (Paraffin) applications. Antigen affinity purified and supplied in PBS with glycerol. Suitable for research use in studying GnRH receptor signaling and related pathways.
- 카탈로그번호
- PA5110782
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GnRHR. Recombinant protein control fragment (Product # RP-105725) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856193 |
Product Specific Information
Immunogen sequence:
MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIR
Target Information
This gene encodes the receptor for type 1 gonadotropin-releasing hormone (GnRHR). It belongs to the seven-transmembrane, G-protein coupled receptor (GPCR) family. The receptor is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate tissues. Upon binding of gonadotropin-releasing hormone, it activates G-proteins that stimulate the phosphatidylinositol-calcium second messenger system, leading to the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Mutations in this gene can cause hypogonadotropic hypogonadism (HH). Multiple transcript variants and isoforms are produced due to alternative splicing and multiple transcription initiation sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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