Thermo Fisher Scientific IL5RA Polyclonal Antibody
IL5RA 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot, IHC, Flow cytometry 등에 사용 가능하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 49–76 amino acids from the N-terminal region of human IL5RA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542659 |
Target Information
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that, together with the alpha chain, forms the high-affinity receptor. The cytoplasmic domains of both chains are essential for signal transduction. The membrane-proximal proline-rich sequence of the IL-5Rα subunit is critical for IL-5–induced proliferative responses, expression of nuclear proto-oncogenes, and tyrosine phosphorylation of cellular proteins such as JAK1 and JAK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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