Thermo Fisher Scientific ATXN7L3 Polyclonal Antibody
Human ATXN7L3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 실험에 적합합니다. SAGA 복합체 관련 전사 조절 연구에 활용 가능하며, 고순도 항원 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific ATXN7L3 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of human ATXN7L3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636641 |
Product Specific Information
This antibody detects endogenous levels of total ATXN7L3 protein.
Target Information
ATXN7L3 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.
Within the SAGA complex, it participates in a subcomplex that specifically deubiquitinates histones H2A and H2B (PubMed:18206972, PubMed:21746879).
The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription and nuclear receptor-mediated transactivation.
ATXN7L3 is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972), regulates H2B monoubiquitination (H2Bub1) levels, and affects subcellular distribution of ENY2, USP22, and ATXN7L3B (PubMed:27601583).
[UniProt]
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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