Thermo Fisher Scientific MET Monoclonal Antibody (OTI3G5), TrueMAB
Human MET 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI3G5). Western blot 및 IHC(P)에서 검증됨. 1 mg/mL 농도의 액상 제품으로, PBS/1% BSA/50% glycerol buffer에 보존. 암 연구 및 MET 신호전달 연구용으로 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 570–885 of human MET produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, it plays roles in wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling has been associated with cancers such as gastric, renal, and breast cancer, making it a key target for cancer therapeutics and diagnostic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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