Thermo Fisher Scientific Pannexin 1 Polyclonal Antibody
Rabbit polyclonal antibody against human Pannexin 1 for Western blot applications. Recognizes C-terminal region of PANX1. Suitable for detecting Pannexin 1 in U2OS cells. Supplied in liquid form, purified by antigen affinity chromatography, and stored ...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Pannexin 1. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736321 |
Product Specific Information
- Positive Control: U2OS
- Predicted Reactivity: Rat (81%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins that are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels.
Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 forms a mechanosensitive ATP-permeable channel between adjacent cells and within the endoplasmic reticulum. It may function as a Ca²⁺-leak channel to regulate ER Ca²⁺ homeostasis and influence neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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