Thermo Fisher Scientific BUBR1 Monoclonal Antibody (8G1), DyLight 650
DyLight 650 형광 표지된 BUBR1 단클론 항체로 인간 세포에서 mitotic checkpoint 단백질 분석에 적합. Western blot, ICC/IF, Flow cytometry 등에 사용 가능. 고순도 Mouse IgG1 항체로 4°C 암소 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BUBR1 Monoclonal Antibody (8G1), DyLight 650
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
- View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8G1 |
| Immunogen | A portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1–350 of human BUBR1) |
| Conjugate | DyLight™ 650 |
| Excitation / Emission Max | 651 / 673 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153072 |
Additional Formats
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defects in spindle checkpoint control contribute to genetic instability and cancer development. Human cells express two related checkpoint kinases, hBUBR1 and hBUB1, both of which monitor kinetochore–microtubule interactions. hBUBR1 prevents premature anaphase entry and has been detected in various human cancers. It also interacts with BCSG1 (Breast Cancer-Specific Gene 1), potentially accelerating breast cancer progression by compromising checkpoint control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.