Thermo Fisher Scientific WASH1 Polyclonal Antibody
Thermo Fisher Scientific의 WASH1 Polyclonal Antibody는 인간 WASH1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC(P), ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS, 40% 글리세롤 보존액에 포함되어 장기 보관이 용이합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WASH1. Recombinant protein control fragment (Product #RP-92149). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649525 |
Product Specific Information
Immunogen sequence:
GAPREVVDPS GGWATLLESI RQAGGIGKAK LRSMKERKLE KKKQKEQEQV RATSQGGHLM SDLFNKLVMR HKGISGKGPG AGEGPGGAFA RVSDSIPPLP PPQQPQVDED EDDWES
Highest antigen sequence identity:
- Mouse: 87%
- Rat: 89%
Target Information
WASHC1 (WASH1) is a protein-coding gene involved in endocytosis and acts as a nucleation-promoting factor (NPF) at endosome surfaces. It recruits and activates the Arp2/3 complex to induce actin polymerization, playing a critical role in endosomal tubule fission and sorting.
Key functional roles include:
- Regulation of endocytic trafficking of EGF and transferrin receptor recycling
- Control of integrin α5β1 trafficking to the plasma membrane
- Involvement in T-cell receptor recycling and MHC class II trafficking in dendritic cells
- Participation in Arp2/3 complex-dependent actin assembly during Salmonella typhimurium invasion
- Contribution to MMP14 exocytosis and matrix remodeling during invasive migration
- Negative regulation of autophagy via inhibition of BECN1 ubiquitination
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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