Thermo Fisher Scientific Human TL-1A, Animal-Free Recombinant Protein, PeproTech
Human TL-1A 동물유래 성분이 없는 재조합 단백질로, E. coli 발현 시스템에서 생산됨. IFN-γ 생성 자극 활성을 지니며 ≥98% 고순도. 염색체 유래 TNF 계열 사이토카인으로, NF-κB 및 MAP kinase 활성화에 관여. 연구용으로만 사용 가능.
- 카탈로그번호
- AF-310-23-xxx (4개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
4개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human TL-1A, Animal-Free Recombinant Protein, PeproTech
Applications
- Functional Assay (Functional): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | MQLRAQGEAS VQFQALKGQE FAPSHQQVYA PLRADGDKPR AHLTVVRQTP TQHFKNQFPA LHWEHELGLA FTKNRMNYTN KFLLIPESGD YFIYSQVTFR GMTSECSEIR QAGRPNKPDS ITVVITKVTD SYPEPTQLLM GTKSVCEVGS NWFQPIYLGA MFSLQEGDKL MVNVSDISLV DYTKEDKTFF GAFLL |
| Molecular Weight | 22.1 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Stimulates IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human TL-1A is a 22.1 kDa polypeptide consisting of 195 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells but not in B or T cells. Expression is inducible by TNF and IL-1 alpha.
This cytokine acts as a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6, activating NF-kappaB and MAP kinases. It functions as an autocrine factor inducing apoptosis in endothelial cells and inhibits endothelial cell proliferation, potentially serving as an angiogenesis inhibitor.
An additional isoform encoded by an alternatively spliced transcript variant has been reported, though its sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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