Thermo Fisher Scientific RCC1 Polyclonal Antibody
RCC1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 인간 단백질에 반응하며 Ran-GTP 교환 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RCC1. Recombinant protein control fragment (Product #RP-94479) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646423 |
Product Specific Information
Immunogen sequence:
IPKSKKVKVS HRSHSTEPGL VLTLGQGDVG QLGLGENVME RKKPALVSIP EDVVQAEAGG MHTVCLSKSG QVYSFGCNDE
Sequence identity with orthologs:
- Mouse: 90%
- Rat: 90%
Target Information
RCC1 (Regulator of Chromosome Condensation 1) is a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. It regulates chromosome condensation during the S phase, binds nucleosomes and double-stranded DNA, and functions as part of a signal pathway detecting unreplicated DNA. The RCC1-Ran complex plays a crucial role in nucleo-cytoplasmic transport, mitosis, and nuclear-envelope assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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