Thermo Fisher Scientific UBE2E3 Monoclonal Antibody (OTI4G4), TrueMAB

Applications

• Western Blot (WB): 1:500–1:2,000
• Flow Cytometry (Flow): 1:100

Product Specifications

Target Information

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates.

1. E1 enzyme activates the Ub C-terminus using ATP.
2. E2 enzyme (UBE2E3) conjugates Ub to form the Ub-E2 intermediate complex.
3. E3 ligase transfers Ub from E2 to the target protein substrate.

UBE2E3, also known as UBCH9, catalyzes the covalent attachment of ubiquitin to other proteins and plays a role in regulating transepithelial sodium transport in renal cells. It may also be involved in cell growth arrest. The protein shuttles between the cytoplasm and nucleus in an IPO11-dependent manner and is expressed ubiquitously at low levels, with high expression in skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.