Thermo Fisher Scientific JAK3 Monoclonal Antibody (2A5)

Applications

• ELISA (ELISA)
  Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSESPP PTHPTPASPK SRLFFPPLF

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family.
JAK3 is predominantly expressed in immune cells and transduces signals in response to activation of interleukin receptors.
Upon cytokine or related factor stimulation (e.g., interferons, interleukins), JAKs are activated via phosphorylation at adjacent tyrosine residues.
Activated JAKs phosphorylate STAT proteins, which dimerize and translocate to the nucleus to modulate transcription of numerous genes, including interferon-stimulated genes.
JAK2 is required for IFN-γ receptor complex initiation, while JAK1 functions as an amplifier. JAK3 may substitute for JAK2 or Tyk2 depending on complex positioning.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.