Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI2H5), TrueMAB
L1CAM/CD171 단백질을 인식하는 마우스 모노클론 항체로, Western blot, IHC, ICC, Flow, IP 등 다양한 응용에 적합. 인간 시료 반응성, 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 연구용에 최적화됨.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2–4 µg/mg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H5 |
| Immunogen | Full length human recombinant protein of human L1CAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family.
The ectodomain consists of several immunoglobulin-like domains and fibronectin-like type III repeats, linked via a single transmembrane sequence to a conserved cytoplasmic domain.
This cell adhesion molecule is crucial for nervous system development, including neuronal migration and differentiation.
Mutations in the gene cause three X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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