Thermo Fisher Scientific FIR Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 FIR 단백질의 내부 영역에서 유래한 합성 펩타이드에 대한 특이적 인식. Western blot에 적합하며, 비결합형 액상 형태로 제공. 뇌, 폐, 고환 등에서 발현되는 FARP2 단백질 연구에 활용 가능.
- 카탈로그번호
- PA538552
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human FIR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2555151 |
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons.
FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2’s Rac GEF activity, which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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