
Thermo Fisher Scientific MCMBP Polyclonal Antibody
Human MCMBP 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western Blot에 적합하며 고순도 항원 친화 크로마토그래피로 정제됨. 다양한 종에서 교차 반응 예측 가능. 연구용으로 사용되며 장기 보관 시 -20°C에서 보관 권장.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MCMBP (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.74 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 0.1M glycine, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736128 |
Product Specific Information
- Positive Control: 293T, A431
- Predicted Reactivity: Mouse (96%), Rat (95%), Dog (97%), Pig (100%), Chicken (90%), Rhesus Monkey (100%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases.
Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate ERK1 and ERK2 MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop.
MEK1 and MEK2 are also activated by dual phosphorylation, occurring on serine 218 and 222 in the activation loop of MEK. Threonine 292 of MEK1 is phosphorylated by ERK2, serving as a negative feedback loop by suppressing activation of MEK1.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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