Thermo Fisher Scientific UBASH3A Polyclonal Antibody
UBASH3A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 ICC/IF에 적합하며, 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며, 내인성 UBASH3A 수준 검출에 사용. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UBASH3A (Accession P57075), corresponding to amino acid residues A313–K363 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851349 |
Product Specific Information
Antibody detects endogenous levels of total UBASH3A.
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized in both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain and is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes. TULA can form homodimers or homo-oligomers that interfere with receptor-type tyrosine kinase degradation, promoting accumulation of activated receptors on the cell surface. It is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The TULA gene, located on human chromosome 21, may be implicated in type I diabetes pathogenesis. Multiple isoforms exist due to alternative splicing.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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