Thermo Fisher Scientific SMC1A Monoclonal Antibody (OTI5A1), TrueMAB
SMC1A 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 및 생쥐 시료에 반응하며, 고순도의 액상 형태로 제공됩니다. 염색체 구조 유지 및 분열 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 889–1016 of human SMC1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression.
These proteins are conserved in eukaryotes and their dysfunction can lead to mitotic chromosome segregation defects, indicating their importance in chromosome dynamics.
SMC1 and SMC3 form a heterodimeric complex essential for metaphase progression and sister chromatid cohesion. Mutations in the SMC1A gene are associated with Cornelia de Lange syndrome 2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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