Thermo Fisher Scientific DACT2 Polyclonal Antibody
Human DACT2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20~1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. Wnt 신호전달 및 DACT2 기능 연구에 적합.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC(P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DACT2. Recombinant protein control fragment (Product #RP-94929). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640369 |
Product Specific Information
Immunogen sequence:
PWGTFWPRPV STGDLDRALP ADTGLQKASA DAELLGLLCQ GVDIPLHVPD PKYRQDLVSQ GGREVYPYPS PLHAVALQSP LFVLTKETPQ
Sequence identity:
- Mouse: 67%
- Rat: 70%
Target Information
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are expressed in postnatal tissues such as the brain.
Dact2, a member of the Dact protein family, binds to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus, kidneys, and salivary gland.
It is thought to play a distinct role from Dact1, with Dact2 having a greater impact on a β-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2—but not Dact1—can inhibit Nodal signaling by promoting endocytic degradation of TGF-β receptors. At least two isoforms of Dact2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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