Thermo Fisher Scientific MMP13 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5-50 µg/mL

-

Product Specifications

Species Reactivity

Rabbit

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein Matrix Metalloproteinase 13. The antigen corresponds to amino acid range 70-245 of the target protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MMP13,uniProtId:O62806-1,ncbiNodeId:9986,antigenRange:70-245,antigenLength:471,antigenImageFileName:PA5-119271_MMP13_O62806-1_Guinea_pig.svg,antigenImageFileNamePDP:PA5-119271_MMP13_O62806-1_Guinea_pig_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2903769

Target Information

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.