Thermo Fisher Scientific Complement C5 Monoclonal Antibody (10B6)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Besides C5, the antibody also recognizes C5b6, but not C6.

Target Information

C5 (Complement C5) is a protein-coding gene. Diseases associated with C5 include Complement Component 5 Deficiency and Eculizumab Poor Response. Related pathways include GPCR downstream signalling and Acquired partial lipodystrophy (Barraquer-Simons syndrome).
Gene Ontology (GO) annotations include signaling receptor binding and endopeptidase inhibitor activity.
An important paralog of this gene is C3.
This gene encodes a component of the complement system, part of the innate immune system that plays a key role in inflammation, homeostasis, and defense against pathogens.
The encoded preproprotein is processed to generate multiple protein products, including C5 alpha chain, C5 beta chain, C5a anaphylatoxin, and C5b.
C5 consists of alpha and beta chains linked by a disulfide bridge.
Cleavage of the alpha chain by convertase forms C5a (a potent spasmogenic and chemotactic factor) and C5b (a subunit of the membrane attack complex, MAC).
Mutations in this gene lead to complement component 5 deficiency, characterized by recurrent bacterial infections.
Alternative splicing produces multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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