Thermo Fisher Scientific PAI1 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1079)

Applications

• ELISA (assay-dependent)

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

PAI1 (plasminogen activator inhibitor 1) belongs to the serine protease inhibitor superfamily and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA).
Platelets are the main source of circulating PAI1, but it is also synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells.
Expression of PAI1 can be regulated at the transcriptional level by various factors such as growth factors, cytokines, hormones, inflammatory mediators, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors.
PAI1 is present at increased levels in various disease states and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia, and metabolic syndrome.
Defects in PAI1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator and may promote neuronal survival.
Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.