Thermo Fisher Scientific GFI1B Polyclonal Antibody
GFI1B 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫에서 반응. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태, 1 mg/mL 농도, 장기 보관은 -20°C 권장.
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Thermo Fisher Scientific GFI1B Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- 1:500–1:1,000
Publications
- 해당 항목 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human GFI1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719471 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages.
It is part of the RCOR-GFI-KDM1A-HDAC complex that suppresses genes involved in multilineage blood cell development via histone deacetylase (HDAC) recruitment and controls hematopoietic differentiation.
GFI1b acts as both transcriptional repressor and activator depending on promoter and cell type context. It represses SOCS1 and SOCS3 promoter activity, regulating cytokine signaling pathways.
Additionally, GFI1b cooperates with GATA1 to repress transcription of target genes such as BCL2L1, influencing apoptosis regulation.
Mutations in GFI1B are associated with Bleeding disorder, platelet-type 17 (BDPLT17).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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