Thermo Fisher Scientific CDC2 (CDK1) Polyclonal Antibody
Rabbit polyclonal antibody against CDC2 (CDK1), reactive with human, bovine, and chicken. Validated for WB and IHC-P. Supplied in liquid form, 0.5 mg/mL, purified by antigen affinity chromatography. Ideal for detecting nuclear CDK1 in cell cycle studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -GTYGV- without a phosphorylation site at Tyr15 of human CDC2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: A431 cell lysate
- Cellular location: Nuclear
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis. CDK1 acts as the catalytic subunit of the M-Phase Promoting Factor, a protein kinase complex that induces entry into mitosis and is conserved among eukaryotes. Phosphorylation of Bcl-2 during G2/M phase arrest involves CDK1-mediated signaling and delays apoptosis onset. CDK inhibitors, such as NU2058, have demonstrated therapeutic potential in androgen-independent prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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