Thermo Fisher Scientific RRAS Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signal pathways control processes such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between two forms: a GDP-bound inactive form and a GTP-bound active form.

Binding of GTP induces conformational changes in the effector-binding domain of the G-protein. Small GTPases are monomeric G-proteins with molecular masses of 20–30 kDa. Ras is attached to the cell membrane by prenylation. Mutations in the Ras family of proto-oncogenes (H-Ras, N-Ras, K-Ras) are common, found in 20–30% of all human tumors. K-Ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.