Thermo Fisher Scientific SETD1B Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: Mouse lung, Rat lung
• Immunogen sequence:
  SEFEEMTILY DIWNGGIDEE DIRFLCVTYE RLLQQDNGMD WLNDTLWVYH PSTSLSSAKK KKRDDGIREH VTGCARSEGF YTIDKKDKLR YLNSSRAS

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein identified as a critical component in the IFN-β signaling pathways that recruits IRF-3 to RIG-I, leading to activation of NF-κB. VISA interacts with other innate immune pathway components such as TRIF, TRAF2, and TRAF6, and with kinases IKK-α, IKK-β, and IKK-ι through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. At least three isoforms of VISA are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.