Thermo Fisher Scientific PYK2 Polyclonal Antibody
Thermo Fisher Scientific의 PYK2 Polyclonal Antibody는 인간, 마우스, 랫트 등에서 PYK2 단백질을 검출하는 항체로, Western blot에 적합합니다. Affinity chromatography로 정제되었으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTK2B (Accession Q14289), corresponding to amino acid residues L376–V426 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900444 |
Product Specific Information
Antibody detects endogenous levels of total PYK2.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway.
PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, migration, adhesion, spreading, and bone remodeling.
FAK2 is essential for normal levels of marginal B-cells in the spleen and for their migration. It functions in signaling downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress.
Aberrant FAK2 expression may contribute to cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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